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The United Nations Afghanistan Regulations were made to implement United Nations Security Council Resolution 1267 1999 ; and allowed for implementation of resolutions 1333 2000 ; , 1373 2001 ; , 1390 2002 ; , 1452 2002 ; , 1526 2004 ; and 1617 2005 ; calling on UN member states to adopt specific measures against the Taliban and Osama bin Laden or his associates. The United Nations Security Council established a committee pursuant to Resolution 1267 1999 ; to maintain a list of individuals and entities associated with the Taliban or Osama bin Laden the "UN List" ; which are automatically covered by the United Nations Afghanistan Regulations.
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2003 marked the 50th anniversary of the breaking of the human genetic code. Medicine has made dramatic strides since then, and the years ahead promise still greater advances. But these very successes have brought new health challenges, as an ever-increasing number of people live into old age. Meanwhile, in the developing world, epidemics such as AIDS and malaria are raging virtually unchecked. Against this backdrop, innovative medicines offer society its most effective -- and cost-effective -- hope. In the following special report, Pfizer introduces its next generation of.
Acute allergic contact dermatitis answer c ; presents acutely as papules, oozing vesicles and crusting lesions on an erythematous base. Chronic cases appear as lichenification, scaling and fissuring. Allergic contact dermatitis is a type IV T-cellmediated sensitivity to topically applied agents. It requires prior exposure sensitization ; to the antigen. Common allergens include: Poison ivy poison oak Nickel Cobalt Rubber-derived compounds Cosmetic preservatives i.e., formaldehyde, quaternium-15 ; Fragrance Topical antibiotics i.e., neomycin, bacitracin ; Topical anaesthetics i.e., benzocaine ; Diagnosis is established on history and distribution of the lesions. This patient had applied an overthe-counter anti-itch medication containing benzocaine, for example, losartan and marfan.
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The definition of EVR that optimized capture of potential responders where most SVR have EVR; highest sensitivity ; while excluding the largest proportion of nonresponders highest negative predictive value ; was at least a 1- or 2-log decrease in HCV RNA from baseline after 12 weeks of treatment Table 1 ; . A 2-log decrease in HCV RNA was a more efficient definition of EVR than a 1-log decrease in that all of the patients with SVR were captured by both definitions, although the former definition did so with a lower proportion of patients achieving EVR. Thus, fewer patients would need to continue therapy to achieve the optimal outcome. Most patients 74.4% ; achieved a 2-log decrease in HCV RNA by 12 weeks and therefore were justified in continuing therapy Fig. 1 ; . If treatment had been discontinued in the other 25.6% of treated patients, no patients with SVR would have been lost by premature interruption of treatment. Furthermore, all of the subjects who failed to reach EVR were nonresponders 24 weeks after completing a full course of treatment. Looked at another way, those patients who failed to achieve EVR after 12 weeks had no chance of reaching SVR, even if they completed the additional 9 months of treatment that was originally prescribed. Patients who failed to reach EVR did not differ by age, sex, weight, or degree of hepatic fibrosis. However, they were more likely to have genotype 1 for PEG R: 94% vs. 60%, P .001; for PEG R 10.6: 90% vs. 57%, P .001 ; and HCV RNA greater than 2 million copies mL.
We gratefully acknowledge the DuPontMerck Pharmaceutical Company for the donation of losartan DUP-753 ; . The authors greatly appreciate the technical assistance of Reginaldo C. Queirz and Silas P. Barbosa. They also thank Silvana A.D. Malavolta for preparation of the manuscript, and Terezinha G.B. Franco and Fernando L. Capelli for animal care and crestor.
Mortality differences. This result was not confirmed in the subsequent, much larger mortality trial ELITE-II[11]; if anything captopril was non-significantly better, except that it was not as well tolerated as losartan. The Randomized Evaluation of Strategies for Left Ventricular Dysfunction pilot study[12] compared candesartan ARB; three doses ; or enalapril ACE inhibitor; 20 mg . day 1 ; , or the combination of candesartan two doses ; plus enalapril 20 mg . day 1 ; in 768 heart failure patients. The end-point was a combination of left ventricular function, exercise tolerance, quality of life, tolerability and neurohumeral responses. There were no significant differences, except that the combination of ACE inhibitor and ARB reduced blood pressure to a greater extent than did the other regimens and had a greater benefit for left ventricular function. However, the trial monitoring committee were concerned about a trend toward a higher event rate in the combination arm. Although the trial steering committee disagreed, the trial was stopped 6 weeks early. A large mortality study with candesartan Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity ; is underway. The Valsartan Heart Failure Trial VAL-HeFT; presented, but so far unpublished ; tested the effect of adding the ARB valsartan or placebo to the regimens of 5010 heart failure patients mostly New York Heart Association class 2 or 3 ; , most of whom were already on an ACE inhibitor. Perhaps surprisingly there was identical mortality in the two groups, but less hospitalization in the valsartan group. A controversial subgroup analysis identified an adverse effect in those patients receiving an ACE inhibitor, valsartan and a beta-blocker. Many felt that this was probably due to play of chance and that as a posthoc analysis it should be interpreted with caution. However, the overall results of Val-HeFT were not particularly encouraging for valsartan, except in another subgroup analysis of patients who were not on an ACE inhibitor. Thus, despite the initial enthusiasm following ELITE-I, the current general consensus is to favour ACE inhibition where tolerated[13]. Other trials in congestive heart failure are ongoing.
The mucosal PGE2 content in the duodenum was measured after administration of enalapril 1 mg kg ; or losartan 10 mg kg ; in the presence of ANGII 0.25 g kg hr ; bradykinin 30 g kg ; Each agent was given i.v., and 90 minutes later, the whole tissue of the duodenal loop was removed, weighed, and put in a tube containing 100% methanol plus 0.1 M indomethacin 17 ; . Then, the samples were minced by scissors, homogenized, and centrifuged for 10 min at 12000 r.p.m. at 4. The supernatant of each sample was used for determination of PGE2 by EIA using a PGE2 kit Cayman Chemical Co., Ann Arbor, MI, USA ; . Indomethacin 5 mg kg ; or L-NAME 20 mg kg ; was given s.c. 1 hr before administration of the above treatment, while FR172357 1 mg kg ; was given i.v. 15 min before and rosuvastatin!
Calcium laevulinate Calcium laevulinate. Source of calcium for treatment of dietary insufficiency. Calcium levofolinate. The active isomer of LEUCOVORIN. Calcium pantothenate. Source of PANTOTHENIC ACID. Considered a vitamin but no proven deficiency has been discovered. No accepted therapeutic role, but used in some vitamin mixtures. Calcium phosphate. Source of calcium for treatment of dietary insufficiency. Calcium polystyrene sulphonate. Ion exchange resin used to treat electrolyte abnormalities by changing absorption or excretion in the gut. Camphene. See CAMPHOR. Camphor. Used internally as carminative and externally as rubefacient. Candesartan cilexetil. Prodrug, rapidly absorbed and converted to candesartan angiotensin II receptor antagonist with actions and adverse effects similar to LOSARTAN. Used as an antihypertensive and in treatment of heart failure. Rarely, bone marrow suppression has been reported. Cannabis m ; . Dried extract of the plant Cannabis sativa, smoked or taken by mouth for the promotion of mood elevation. The main active principle is tetrahydrocannabinol. Adverse effects include nausea, vomiting, anxiety and psychotic episodes. Tolerance and psychological dependence occur but physical dependence is not a serious problem. Overdose causes exacerbation of the adverse effects and is managed by supportive treatment. Cannabinoids have antiemetic effects. NABILONE is a cannabis derivative used to treat nausea and vomiting from cytotoxic drugs. Capecitabine r ; . Noncytotoxic drug which acts as a precursor for the cytotoxic FLUOROURACIL. Given orally, after absorption it is converted into FLUOROURACIL by enzymes that are present in colorectal cancer. Used to treat metatstatic tumours. Adverse effects include bone marrow suppression and CNS disturbance but better tolerated than when FLUOROURACIL itself is administered. Capreomycin. Peptide antibiotic, mainly used in tuberculosis. Adverse effects include ototoxicity and nephrotoxicity. Capsaicin. Naturally occurring substance found in Capsicum sweet pepper ; . When applied to the skin it depletes local painconducting nerve fibres of pain transmitter substance. Used topically to treat postherpetic neuralgia pain persisting after shingles, which is caused by infection with the herpes zoster virus ; . Claimed to be effective in treating pain after psoralin ultraviolet activation therapy and in erythromelalgia. Should not be applied to broken skin. May cause skin irritation. Capsicum. Essential oil used internally as carminative and externally as rubefacient. Captopril. Inhibits angiotensin-converting enzyme ACE ; involved in formation of hormone concerned with maintenance of blood pressure and constriction of blood vessels. Used in treatment of hypertension, kidney disease in diabetic patients, chronic heart failure and in prevention of recurrent myocardial infarction. Adverse effects include hypotension, proteinuria and renal impairment, skin rashes and cough. Bone marrow depression and loss of taste may occur with high doses. Caraway. Essential oil used as carminative. Carbachol. Parasympathomimetic, with actions and adverse effects similar to ACETYLCHOLINE, but more prolonged. Used as miotic eye drops in glaucoma and for improvement of postoperative intestinal or bladder muscle tone. Carbamazepine. Anticonvulsant. Acts by suppressing epileptic discharges in the brain. Used in prevention of epilepsy, in suppression of pain in trigeminal neuralgia.
Unfortunately, multiple studies have shown losartan to be less effective than the newer arbs and tranexamic.
Medication, pregnancy and lactation an internet resource for health professionals and other interested people.
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WHEN SEEKING MEDICAL MONITORING? The Seventh Amendment provides that "[i]n Suits at common law, where the value in controversy shall exceed twenty dollars, the right of trial by jury shall be preserved." U.S. Const. Amend. VII.30 In Barnes v. American Tobacco Co., plaintiffs seeking the creation of a medical monitoring fund requested that the case be tried to the court, arguing that they were seeking only injunctive relief. See 989 F. Supp. 661, 663 E.D. Pa. 1997 ; . In response, defendants filed a motion to enforce their demand for a jury trial. See id. The court first determined that while there was no common law cause of action for medical monitoring in 1791, the underlying theory of medical monitoring is negligence, which was an action at law in 1791.31 See id. at 664. Thus, the first prong of the court's Seventh Amendment analysis weighed in favor of granting the defendants a jury trial. See id. at 665. The defendants contended that plaintiffs were seeking legal not equitable relief, since defendants would ultimately have to pay for the creation of a medical monitoring fund. See id. Referring to its earlier opinion in Arch, 175 F.R.D. at 483, the court determined that the creation of a medical monitoring fund was an exercise of the court's equitable powers. See Barnes, 989 F. Supp. at 666. Thus, the second prong of the court's Seventh Amendment analysis weighed against the defendants' right to a jury trial. However, the court concluded that the defendants were entitled to a jury trial because "a plaintiff . cannot invoke the powers of equity when there is an adequate remedy at law." Id. at 667. The court reasoned that the plaintiffs had an adequate remedy at law, since they could have requested lump sum damages. See id. The plaintiffs' unilateral decision to forego this remedy could not deprive the defendants of their right to a jury trial. See id. at 667-68. Finally, the Barnes court explained that the standard for demonstrating an action is legal for Seventh Amendment purposes is lower than for Rule 23 b ; 2 ; purposes. See id. An action may be certified under Rule 23 b ; 2 ; the relief requested is not primarily for money damages. See id. However, the Seventh Amendment right to jury trial must be upheld even if the legal issues are incidental to equitable issues. See id. Thus, a court may certify a medical monitoring class under Rule 23 b ; 2 ; and still rule that defendants are entitled to a jury trial and cymbalta.
Kit rather than different kits for males and females. The collected swab specimen is stable for up to 60 days at room temperature. The amplified test allows the testing of urine for males and females. The use of the urine specimen is an attractive feature for settings in which there are barriers to performing a pelvic examination or collecting a urethral swab. The urine must be first-catch 2030 ml of the initial urine stream ; rather than mid-stream, to ensure the collection of inflammatory cells. Amplified tests improve the sensitivity of the Chlamydia trachomatis assay by detecting subclinical and early infections in which the microbial number is low. The benefits of amplification are less pronounced for gonorrhoea because there are more microorganisms in the specimen. Test performance always varies with the patient population, and individual laboratory results might vary. Table 4 shows the test performance data for the Gen-Probe APTIMA test generated by the manufacturer.4 These data indicate that the assay is both highly sensitive and specific for males and females, and that urine is virtually equivalent to genital swabs as a specimen source when using the latest amplified probe technology. There are some additional characteristics of the amplified nucleic acid test that some physicians may encounter. The APTIMA test, like all other commercial amplified tests, is not FDA-approved for use in forensic cases when the result is to be used for evidence. This amplified probe test may be used for diagnosis and treatment of any forensic case, but culture must also be collected as evidence. The APTIMA test is approved for urine, endocervical swabs, and male urethral swabs. The test is not approved for other specimens like throat, rectum, conjunctival, infant lower respiratory, etc. Laboratories that use molecular tests have developed some helpful hints for physicians to avoid some common mistakes. Please remember that these commercial tests are highly regulated by the FDA.
Lithium carbonate, 25 lithium carbonate ext-rel tabs 300 mg, 25 lithium carbonate ext-rel tabs 450 mg, 25 LITHOBID, 25 LO OVRAL, 27 LOFIBRA, 20 LOMOTIL, 29 lomustine, 18 loperamide, 29 LOPID, 20 lopinavir ritonavir, 17 LOPRESSOR, 21 LOPROX, 35 loratadine, 33 loratadine pseudoephedrine ext-rel, 33 lorazepam, 22 LORTAB 10 500, 14 LORTAB 7.5 500, 14 LORTAB ELIXIR, 14 losartan, 20 losar6an hydrochlorothiazide, 20 LOTEMAX, 37 loteprednol 0.5%, 37 LOTREL, 19 lovastatin, 20 LOVENOX, 31 LUMIGAN, 37 LUPRON, 18 LUPRON DEPOT, 18 LURIDE, 32 LURIDE LOZI-TABS, 32 LYRICA, 22 LYSODREN, 19 MACROBID, 18 MACRODANTIN, 18 malathion, 36 MATULANE, 19 MAXAIR, 33 MAXALT MAXALT-MLT, 24 MAXITROL, 36 MAXZIDE, 21 mebendazole, 17 meclizine, 29 MEDROL, 28 medroxyprogesterone acetate, 28 medroxyprogesterone acetate 150 mg mL, 28 mefloquine, 16 MEGACE, 18 MEGACE ES, 18 megestrol acetate, 18 megestrol acetate susp, 18 melphalan, 18 memantine, 22 MEPRON, 17 mercaptopurine, 18 mesalamine delayed-rel tabs, 29 mesalamine rectal susp, 30 mesalamine supp, 30 MESTINON, 25 MESTINON TIMESPAN, 25 METADATE ER, 24 and duloxetine.
The data were expressed as median range ; Abbreviation: NS Non significant p 0.05 ; Table 4. Net ultrafiltration during 4-hour dwelling in the oral ISMN and placebo groups ISMN N 9 ; Net ultrafiltration mL ; 120 100-240 ; Placebo N 9 ; 110 80-200 ; p-value NS, for example, l9sartan chemical.
This study extends the present knowledge on the role of sympathetic hyperactivity in CRF 1 ; . It confirms that normovolemic hypertensive CRF patients have an activated renin and sympathetic nervous system and that in these patients ACEinhibition with enalapril can effectively lower BP and ameliorate the sympathetic hyperactivity. News in our study is that losartan, in a dosage with a comparable BP lowering effect, also reduces the sympathetic hyperactivity, not, however, better than enalapril and cytotec.
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Among the changes that occurred worldwide during the 1960s, the Cuban revolution, which began in 1959, emerged as one of the most important for social medicine. Cuba's improved public health system emerged as part of a social revolution in which accomplishments in health occurred as an integral part of broad structural changes in the society as a whole.36, 37 The social changes underlying Cuba's, for example, what is losrtan potassium.
Losartan is a member of the most recent class of antihypertensives known as angiotensin ii antagonists aiia and misoprostol.
In this study of previously healthy young swine with experimental right ventricle infarct, the following conclusions can be drawn: 1. Aminophylline was demonstrated to cause an appreciable transitory decrease in pulmonary vascular resistance, and a similar short-lived increase in cardiac index. Coupled with an increase in heart rate, however, the overall effect was a decrease in left-side preload and subsequently in cardiac performance. It is recommended that aminophylline be used with caution for pulmonary vasodilation in patients suffering right heart failure due to infarct and that left-heart preload be carefully optimized in these subjects. A continuous infusion of adenosine at various rates was shown to effectively decrease both systemic and pulmonary afterload and thereby improve cardiac output after right heart infarct. The effects on pulmonary pressure were observable, but not as marked. Discontinuation of the infusion led to an increase in both systemic and pulmonary resistances, as well as a decrease in cardiac index. The infusion of adenosine therefore appears to cause an unloading of the right heart and an improvement in inotropy. The vasodilative effect extended to the systemic vasculature at higher doses. Llosartan induced a significant improvement in cardiac performance with a concurrent reduction in both right and left heart preload. Of equal importance, both systemic pressures and heart rate were maintained. Due to the longer half-life of this drug in humans, it may be an effective regime in the treatment of heart failure after right heart infarct. Nitric oxide appears to effectively unload the right heart, even in subjects with normal pulmonary vasculature. It also effects a decrease in left-side preload, however, as well as a deterioration in cardiac pump performance and systemic pressures. When using nitric oxide in a clinical situation, special attention should be paid to its effects on left heart preload and myocardial performance.
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Indeed, in most trials of chf in which losartan is used, the strategy is to add it to ace inhibitors to provide additional blockade of the renin-angiotensin system and calcitriol.
Mechanism that does not involve PLC. However, both adrenal AT1 receptor subtypes cloned thus far are coupled to PLCmediated Ca2 mobilization. Perhaps identical AT1 receptors are linked to several signaling pathways through one or more G proteins. In addition to activating PLC, losartan-sensitive AT1 receptors in some cells are also coupled to adenylate cyclase inhibition through a PTx-sensitive G protein 8 ; . This second AT1coupled pathway appears to be unrelated to IAC inhibition and cortisol secretion in AZF cells since the associated G protein is PTx insensitive. Inhibition of cAMP synthesis would suppress rather than stimulate cortisol secretion. Phospholipase C-independent Inhibition of IAC--Several lines of evidence indicated that AII-mediated inhibition of IAC was independent of PLC. The inability of acetylcholine to inhibit IAC at concentrations that produce maximal activation of PLC and cortisol secretion 6, 17 ; in bovine AZF cells argues against a role for this enzyme in IAC inhibition, at least under the conditions of our patch clamp experiments. The failure of PLC antagonists neomycin 18, 30, 31 ; and manoalide 22 ; to.
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Viability and caspase 3 7 activity in Jurkat cells. Conclusions The combination of the highly functional Dharmacon siGENOME siRNA reagents and the amaxa NUCLEOFECTOR technology provides a unique and powerful method for delivering SMARTpool siRNA reagents and siARRAY siRNA libraries into cells that have been considered intractable to lipid and rocaltrol and losartan, because losartan 100mg.
These medications decrease appetite by increasing the availability of serotonin or catecholamine - two brain chemicals that affect mood and appetite.
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Facilitates a femoral approach The familiar handle and bi-directional steering of the SteeroCath-DxTM Catheter help guide the catheter through tortuous vasculature from the femoral vein up to the right atrium. After the catheter is positioned along the tricuspid annulus at the His-bundle location, it is deflected caudally and rotated posteriorly clockwise ; into the CS ostium. Fluoroscopic imaging in the LAO view and inspection of the electrograms can be used for guidance. Once the tip of the catheter is engaged in the ostium of the CS, the curve is relaxed and the catheter is advanced with continued clockwise rotation. The bi-directional curve can be used to point the tip of the catheter cranially as the catheter is advanced within the body of the CS to avoid entry into lateral branches. Soft tip, superior steerability Many features of the SteeroCath-Dx Catheter facilitate CS cannulation from an inferior approach. These include a soft tip, a curve radius that is appropriate for most patients, and a shaft that provides superior steerability, pushability, and torqueability. Navigation of the SteeroCath-Dx Catheter through tortuous vessels and within the heart is facilitated by two additional features: the adjustable curvetension lock feature, and the in-plane steering feature that provides a measure of predictability by keeping the catheter tip deflection in the same plane as the flat part of the handle. Enhanced stability The SteeroCath-Dx Catheter provides excellent recordings and remains stable after positioning in the CS as demonstrated in Figures 2 and 3. Stability can be particularly important during and carbamazepine.
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10. Mallion JM and Lacourciere Y: Blood Pressure Monitoring Group A Comparison of the Blood Pressure Profile of Telmisartan and Losartaan at 18-24 Hours Post Dosing As Measured by Ambulatory Blood Pressure Monitoring [abstracts no. E141]. J Hypertens 1998; 11 94 Pt2 ; : 262A. 11. Meredith PA Optimal Dosing Characteristics tensin II Receptor Antagonist Telmisartan. 84"7K, 1999. of the Anglo J Cardlol.
Effect of losartan, an angiotensin ii antagonist, on hepatic fibrosis induced by ccl4 in rats.
For Health Research and Quality AHRQ ; , "Comparative long-term benefits and harms of ACEIs versus ARBs for treating hypertension, " ignoring reported differences in BP efficacy and medication persistence between ACEI and ARBs. The report states that there are significant differences in several assessments, including BP lowering, frequency of cough, and persistence. This is perhaps an irrelevant point, since this report is only at the draft stage and has serious limitations that still need to be addressed before it is finalized. The editorial questions the long-term safety of ARBs, citing the AHRQ report. However, the report conclusions regard ing long-term differences between ACEIs and ARBs are severely limited by the duration and quality of the studies included, with nearly 70% being of 6 months' duration or less. The report analyses assume that agents within a class are equivalent i.e., a class effect ; and, therefore, minimize differ ences among the individual agents and disregard evidence-based medicine. For example, both candesartan and irbesartan have demonstrated greater BP-lowering efficacy over losartan in 2 well-controlled clinical studies at maximum doses, meeting stringent U.S. Food and Drug Administration requirements for superiority claims.3-5 The editorial selectively cites literature on medication adherence for patients receiving ACEIs. Several studies that were not cited in the editorial demonstrate significantly higher compliance and lower discontinuation rates with ARBs compared with ACEIs.6, 7 Compliance and adherence are recognized cost drivers for managed health care. An important point that should be taken into account is that clinical studies with ARBs are more recent than studies with ACEIs, which were conducted in the 1990s, when the prevalence of metabolic syndrome and type 2 diabetes mellitus was considerably less in the United States. There are now data with ARBs in "difficult-to-treat" hypertensive patients8 that cannot be extrapolated to the older studies with ACEIs in a less severe hypertensive population. In addition, the change in population risk, with higher failure rates with monotherapy and differences in compliance, make the cost estimates unrealistic. Hypertension control continues to be a tremendous unmet medical need in the United States, with approximately two thirds of the 72 million Americans with high blood pressure not meeting recommended target blood pressure goals.9, 10 ARBs and ACEIs are integral medications in the antihypertensive armamentarium. Although both drug classes inhibit the reninangiotensin aldosterone system, important clinical differences exist between the classes as well as within each class that are important for physicians to consider when trying to optimize care for individual patients. In light of the asymptomatic nature of hypertension and often lifelong duration of therapy for individuals who have high blood pressure, artificially limiting the important treatment choices for physicians and patients.
Address correspondence to: Agnes Tran, Ecole Pratique des Hautes Etudes, ` Pharmacologie, Hopital Saint Vincent de Paul, 82 avenue Denfert-Rochereau, 75674 Paris cedex 14, France. E-mail: agnes.tran svp.aphp, for instance, losartan clinical trials.
Although it is legal for physicians to prescribe medications for off-label uses, it is not legal for a drug company to promote unapproved uses or distort information about a medication' s off-label benefits and crestor.
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