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Clearly it would be desirable to provide an agent which could be applied topically to treatocular hypertension and glaucoma without an unacceptable level of such side effects.

Although catecholamine secretion is common in neuroblastomas, ganglioneuromas were formerly thought to be endocrinologically inactive. However, one series of 46 patients found elevated plasma or urinary catecholamines in 39%.1 Another series of 25 patients found a trend for metabolic activity to correlate with tumour size.11 Ganglioneuromas have rarely been reported as being VIP-secreting, when they are frequently associated with severe watery diarrhoea.12 123I-mIBI uptake has also been well described in ganglioneuroma, tending to occur in functionally active tumours.1 On this occasion scintigraphy was not required for diagnosis. CT is the radiological investigation of choice when establishing the diagnosis of ganglioneuroma, as the appearances can be characteristic and are well described.13, 14 In this case, findings were consistent with those previously reported: that of a round or oval tumour encasing the great vessels with or without calcification and a tumour capsule. Where intra-spinal involvement is suspected, MRI should be performed as it is superior to CT in this regard.13 Ganglioneuroma is a benign neoplasm consisting of relatively mature ganglion cells arranged in groups, surrounded by a Schwann cell-rich stroma. They are most commonly asymptomatic. Less than 30% are adrenal in origin, the remainder are located in the posterior mediastinum, retroperitoneum or other sites15 including the small and large intestine.16 The gross appearance is usually of a sharply circumscribed mass without a true capsule and a cut surface, which is grey tan with some gelatinous firm and whorled regions. At light microscopy, ganglioneuromas have a variable number of mature ganglion cells. The cells may be binucleate and misshapen. The stroma consists of Schwann cells and variable amounts of collagen. Immunohistochemical identification of neurofilament and S100 is useful in the diagnosis and the cell proliferation index marker and cyproheptadine!

P. VENKATA REDDY and B. SUDHA RANI * University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530003, A.P. ; , INDIA and ditropan!

There is accumulating evidence that 3-hydroxy-3methylglutaryl coenzyme A reductase inhibitors, or statins, exert numerous beneficial effects that are apparently independent of their action on blood lipids 13 ; . These include effects on the cardiovascular system, kidneys, bone, and glucose metabolism. A number of clinical trials have shown that statins significantly reduce cardiovascular morbidity and mortality. Potential mechanisms that may mediate beneficial cardiovascular action of statins include modulation of endothelial function 4 7 ; , anti-inflammatory action 8, 9 ; , antioxidant properties 10 ; , plaque stabilization 11 ; , and effects on thrombosis 12 ; and vasculogenesis 13 ; . It also worth noting that, although statins share a common lipid-lowering effect, there seem to be differences within this class of drugs, not only in their lipid-lowering potential, but also in their nonlipid effects 14 ; . These potential differences necessitate careful and systematic studies involving each member of the statin family. In the present study we examined cardiovascular effects of.
Fig. 4. Substantial additional IOP-lowering seen when brimonidine 0.2% added to latanoprost monotherapy or to multi-drug regimens containing latanoprost. In a large, open-label trial of 552 patients, brimonidine was added to multi-drug combinations that included latanoprost in a subset of 56 patients. Brimonidine induced a 32.2% decrease in IOP in patients previously treated with latanoprost only n 16 ; . Used adjunctively in patients on a regimen containing latanoprost, a nonselective beta-blocker and dorzolamide, brimonidine induced an additional 20.1% decrease in IOP n 11 ; . This figure was derived from data from Lee and Gornbein.33.

The outcome from the silica manufacturing process. These metal ion species should be distinguished from adsorbed metal ion species, introduced in the final product due to use of metal ion containing solvents, chemicals etc. Adsorbed metal ion species are often possible to remove during a regeneration process, in contrast to the "built-in", strongly bound, metal ions, which are part of the final product. It is well known that strongly electronegative metal ions e.g. bivalent iron and trivalent aluminum ; , in the silica matrix, have the ability to enhance the acidity of silanols in their close proximity, figure 3. Increased acidity of silanols provides a higher possibility for ion-exchange interactions at any given pH. Moreover, metal ions present in the silica surface layer are able to interact directly with analytes having Lewis-base properties, figure 3. The direct metal-analyte interaction is most pronounced for chelating substances, but it also affects the chromatographic behavior of acids, alcohols, amines etc. Three batches of Kromasil silica Kromasil uses a proprietary manufacturing process. The metal content in all reagents and raw materials are minimized due to a rigorous QC procedure. In table 1 you will find information regarding the metal content in three typical batches. Different levels of metal ions a comparison study In the case of a high purity and a high performing silica the accessibility of surface silanols as ionexchange sites or the direct access to metal ions.

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